Chapter 6 Cell Cycle and Cell Division by Teaching Care online coaching classes
Chapter 6 Cell Cycle and Cell Division by Teaching Care online coaching classes
Cell division/Cell reproduction/Cell cycle.
- Introduction : It is the process by which a mature cell divides and forms two nearly equal daughter cells which resemble the parental cell in a number of
“Continuity of life” is an important intrinsic characteristic of living organisms and is achieved through the process of reproduction. The reproduction may be asexual or sexual. Both of these involve the division and replication of cells. Even the growth and development of every living organism depends on the growth and multiplication of its cells.
In unicellular organisms, cell division is the means of reproduction by which the mother cell produces two or more new cells. In multicellular organism also, new individual develop from a single cell. The zygote, by the cell division. Cell division is central to life of all cell and is essential for the perpetuation of the species.
- Discovery : Prevost and Dumas (1824) first to study cell division during the cleavage of zygote of Nagelli (1846) first to propose that new cells are formed by the division of pre-existing cells.
Rudolf virchow (1859) proposed “omnis cellula e cellula” and “cell lineage theory”.
A cell divides when it has grown to a certain maximum size which disturb the karyoplasmic index (KI)/Nucleoplasmic ratio (NP)/Kernplasm connection. Two processes take place during cell reproduction.
- Cell growth : (Period of synthesis and duplication of various components of cell).
- Cell division : (Mature cell divides into two cells).
- Cell cycle : Howard and Pelc (1953) first time described The sequence of events which occur during cell growth and cell division are collectively called cell cycle. Cell cycle completes in two steps:
- M-phase/Dividing phase
- Interphase : It is the period between the end of one cell division to the beginning of next cell It is also called resting phase or not dividing phase. But, it is actually highly metabolic active phase, in which cell prepares itself for next cell division. In case of human beings it will take approx 25 hours. Interphase is completed in to three successive stages.
G1 phase/Post mitotic/Pre–DNA synthetic phase/Gap Ist : In which following events take place.
- Intensive cellular
- Synthesis of rRNA, mRNA ribosomes and
- Metabolic rate is
- Cells become
- Synthesis of enzymes and ATP
- Cell size
- Decision for a division in a cell
- Substances of G stimulates the onset of next S –
- Synthesis of NHC protein, carbohydrates, proteins,
- Longest and most variable
- Synthesis of enzyme, amino acids, nucleotides but there is no change in DNA amount.
- DNA replicates and its amount becomes double (2C – 4C).
- Synthesis of histone proteins.
- Euchromatin replicates earlier than
- Synthesis of NHC (non-histone chromosomal proteins).
- Each chromosome has 2
G2-phase/Pre mitotic/Post synthetic phase/gap-IInd
- Intensive cellular
- Increase in energy
- Mitotic spindle protein (tubulin) synthesis
- Chromosome condensation factor
- Synthesis of 3 types of RNA and NHC
- Synthesis of ATP molecule and
- Duplication of mitochondria,
plastids and other cellular macromolecular complements.
- Damaged DNA repair
(ii) M-phase/Dividing phase/Mitotic phase
- Nuclear division e. karyokinesis occurs in 4 phases – prophase, metaphase, anaphase and telophase. It takes 5-10% (shortest phase) time of whole division.
- Cytokinesis : Division of cytoplasm into 2 equal parts. In animal cell, it takes place by cell furrow method and in plant cells by cell plate
DNA replication M
Active protein and RNA synthesis 30–40%
Fig : Different stages of cell cycle (Mitotic cycle).
- Duration of cell cycle : It depends on the type of cell and external factors such as temperature, food
and oxygen. Time period for
G1 , S,
G2 and M-phase is species specific under specific environmental conditions.
e.g. 20 minutes for bacterial cell, 8-10 hours for intestional epithelial cell, and onion root tip cells may take 20 hours.
- Regulation of cell cycle : Stage of regulation of cell cycle is one of the three
- It may start a new cycle, enter the S-phase and finally
- It may be arrested at a specific point of G1
G1 phase during which a cell may follow
- It may stop division and enter G0
quiscent stage. But when conditions change, cell in G0
resume the growth and reenter the G1 phase.
Types of cell division : It is of three types, Amitosis, Mitosis and Meiosis.
- G0 – phase : The cells, which are not to divide further, do not proceed beyond the G1 phase and start undergoing differentiation into specific such cells are said to be in G0 phase.
- Generation time : Period between 2 successive generation (range 8 hr – 100 days).
- Mitogens : Chemicals which enhance or stimulate cell division g. lymphokinase (in man)
- Cell cycle duration : 20 minutes in bacteria , 20 hrs in root tip of onion, 2-3 hrs in yeast, 24 hrs in
- G0 phase : Cell only starts dividing when the period is favorable otherwise, it remain viable for months or years as such in G0
- During the mitosis of He-La cells, the longest period is gap I phase or G1.
- DNA replication occurs in S-phase.
- In a cell cycle the condensation of chromosome with visible centromere occurs during M-phase.
- Sequence in cell cycle is G1, S, G2, M .
- M-phase is of shortest duration of cell
- In G2 , the damaged DNA is
- Histone protein and RNA synthesis occurs in S-phase.
- Duplication of chromosome occurs at S-
Amitosis : (Gk amitos = without thread, osis = state) It is also called as direct cell division. It was discovered
by Remak (1855) in RBC of chick embryo. In this division there is no differentiation of chromosomes and spindle. The nuclear envelope does not degenerate.The nucleus elongates and constricts in the middle to form two daughter nuclei. This is followed by a centripetal constriction of the cytoplasm to form two daughter cells. It is primitive type of division occuring in prokaryotes, protozoans, yeasts, foetal membrane of mammals, cartilage
of mammals, degenerating cells of the diseased tissues and in the old tissues.
Mitosis : (Gk. Mitos = thread; osis = state)
Fig : Amitosis
- Definition : It is also called indirect cell division or somadtic cell division or equational division. In this, mature somatic cell divides in such a way that chromosomes number is kept constant in daughter cells equal to those in parent cell, so the daughter cells are quantitatively as well as qualitatively similar to the parental cell. So it is called equational
- Discovery : Mitosis was first observed by Strasburger (1875) and in animal cell by fleming (1879) term mitosis was given by Fleming (1882).
- Occurrence : Mitosis is the common method of cell division. It takes place in the somatic cells in the Hence, it is also known as the somatic division. It occurs in the gonads also for the multiplication of undifferentiated germ cells. In plants mitosis occurs in the meristematic cells e.g. root apex and shoot apex.
- Duration : It ranges from 30 minutes to 3 hours time is species-specific but also depends upon type of tissues,
- Process of mitosis : Mitosis is completed in two steps
Karyokinesis : (Gk. karyon = nucleus; kinesis = movement) Division of nucleus. Term given by Schneider
Cytokinesis : (Gk –kitos = cell; kinesis = movement) Division of cytoplasm, Term given by Whitemann
Karyokinesis : It comprises four phases i.e. Prophase, Metaphase, Anaphase, Telophase.
- Prophase : It is largest phase of
- Chromatin fibres thicken and shorter to form chromosomes which may overlap each other and appears like a ball of i.e. Spireme stage.
- Each chromosome divides longitudinally into 2 chromatids which remain
attached to centromere.
- Nuclear membrane starts disintegrating except in
- Nucleolus starts disintegrating.
- Cells become viscous, refractive and oval in
- Spindle formation
- Cell cytoskeleton, golgi complex, ER, disappear.
- In animal cells, centrioles move towards opposite
- Lampbrush chromosomes can be studied
- Small globular structure (beaded) on the chromosome are called
- Chromosomes become maximally distinct e. size can be measured.
- A colourless, fibrous, bipolar spindle
- Spindle is formed from centriole (in animal cells) or MTOC (microtubule organising centre) in plant cells successively called astral and anastral
- Spindle has 3 types of
- Continuous fibre (run from pole to pole).
- Discontinuous fibre (run between pole to centromeres).
- Interzonal fibre (run between 2 centromere).
No Centrosome Nucleus Nucleolus
membrane Cell wall
Equator of spindle
Cell wall New cell wall
New plasma membrane
- Spindle fibre are made up of 97% tubulin protein and 3%
Fig : Various stages of mitosis
- Chromosomes move towards equatorial plane of spindles called congression and become arranged with their arms directed towards pole and centromere towards
- Spindle fibres attach to
- Metaphase is the best stage for studying chromosome
- Centromere splits from the middle and two chromatids gets
- Both the chromatids move towards opposite poles due to repulsive force called anaphasic
- Anaphasic movement is brought about by the repolymerisation of continuous fibres and depolymerisation of chromosomal
- Different shape of chromosomes become evident during chromosome movement metacentric acrocentric etc.
- Chromosomes takes V, J, I or L
- The centromere faces towards
- The chromatids are moved towards the pole at a speed of 1 mm/minute. About 30 ATP molecules are used to move one chromosome from equator to pole.
- Chromosomes reached on poles by the spindle fibers and form two groups.
- Chromosomes begin to uncoil and form chromatin
- The nuclear membrane and nucleolus reappear.
- Two daughter nuclei are
- Golgi complex and ER , reform.
Cytokinesis : It involves division of cytoplasm in animal cells, the cell membrane develops a constitution which deepens centripetally and is called cell furrow method.
In plant cells, cytokinesis occurs by cell plate formation.
(6) Significance of mitosis
Furrow Mid body
Fig : Furrowing Cell plate formation (In animals) (In plants)
- It keeps the chromosome number constant and genetic stability in daughter cells, so the linear heredity of an organism is All the cells are with similar genetic constituents.
- It helps in growth and development of zygote into adult through embryo
- It provides new cells for repair and regeneration of lost parts and healing of the
- It helps in asexual reproduction by fragmentation, budding, stem cutting, etc.
- It also restores the nucleo-plasmic
- Somatic variations when maintained by vegetative propagation can play important role in
(7) Types of Mitosis
- Anastral mitosis : It is found in plants in which spindle has no
- Amphiastral mitosis : It is found in animals in which spindle has two asters, one at each pole of the Spindle is barrel-like.
- Intranuclear or Promitosis : In this nuclear membrane is not lost and spindle is formed inside the nuclear membrane g. Protozoans (Amoeba) and yeast. It is so as centriole is present within the nucleus.
- Extranuclear or Eumitosis : In this nuclear membrane is lost and spindle is formed outside nuclear membrane g. in plants and animals.
- Endomitosis : Chromosomes and their DNA duplicate but fail to separate which lead to polyploidy g. in liver of man, both diploid (2N) and polyploid cells (4N) have been reported. It is also called endoduplication and endopolyploidy.
- Dinomitosis : In which nuclear envelope persists and microtubular spindle is not formed. During movement the chromosomes are attached with nuclear
- Pericentriolar cloud : A clear cytoplasmic area with no cell organelle between the centriole pair and astral
- Root tips of onion are best material for studying
- Kinetochore : A discoidal area on each chromatid and is the site of attachment of spindle
- In mitosis, plectonemic coiling takes place, in which sister chromatids are tightly coiled upon each other and are not easily Paranemic coiling found in meiosis.
- Chromosomal fibres are also called tractile fibres, while continuous fibres are also called interpolar
- Mitogens : The agents which stimulate cell division g., cytokinins, auxins, gibberllins, insulin, temperature, steroids.
- Mitotic poision : The agents which inhibit cell
- Azides and Cyanides : Inhibit
- Colchicine : Inhibits spindle formation at
- Mustard gas : Agglutinates the
- Chalones : These were first reported by Laurence and Bullough (1960). They are peptides and glycoproteins secreated by extracellular fluid of healthy cells and inhibit cellular
- Karyochoriosis : A type of mitosis in fungi in which is intranuclear nucleus divides by furrow
- C-mitosis : Colchicine induced
- After undergoing certain divisions, cells This is called as “ Hayflick limit”.
- Actinomycin D and tetracyclin inhibit cell
- 7 mitotic divisions occur to form embryosac in
- Mitosis index is the ratio of dividing and non-dividing cells.
Meiosis : (Gk. meioum = to reduce, osis = state)
- Definition : It is a special type of division in which the chromosomes duplicate only once, but cell divides So one parental cell produces 4 daughter cells; each having half the chromosome number and DNA amount than normal parental cell. So meiosis is also called reductional division.
- Discovery : It was first demonstrated by Van Benden (1883) but was described by Winiwarter (1900). Term “meiosis” was given by Farmer and Moore (1905).
- Occurrence : It is found in special types and at specific period. It is reported in diploid germ cells of sex organs (g. primary spermatocytes of testes to form male gametes called spermotozoa and primary oocytes to form female gametes called ova in animals) and in pollen mother cells (microsporocytes) of anther and megasporocyte of ovule of ovary of flowers in plant to form the haploid spores. The study of meiosis in plants can be done in young flower buds.
- Process of meiosis : Meiosis is completed in two steps, meiosis I and meiosis II
Meiosis I : In which the actual chromosome number is reduced to half. Therefore, meiosis I is also known as reductional division or heterotypic division. It results in the formation of two haploid cells from one diploid cell. It is divided into two parts, karyokinesis I and cytokinesis I.
Karyokinesis I : It involves division of nucleus. It is divided into four phases i.e. prophase, metaphase, anaphase, telophase.
Prophase I : It is of longest phase of karyokinesis of meiosis. It is again divisible into five subphases i.e.
leptotene, zygotene, pachytene, diplotene and diakinesis.
- Chromosomes are long thread like with chromomeres on
- Volume of nucleus
- Chromatin network has half chromosomes from male and half from female
- Chromosome with similar structure are known as homologous
- Leptonemal chromosomes have a definite polarization and forms loops whose ends are attached to the nuclear envelope at points near the centrioles, contained within an Such peculiar arrangement is termed as bouquet stage (in animals) and syndet knot (in plants).
- M. (electron microscope) reveals that chromosomes are composed of paired chromatids, a dense proteinaceous filament or axial core lies within the groove between the sister chromatids of each chromosome.
- Lampbrush chromosome found in oocyte of amphibians is seen in
- Pairing or “synapsis” of homologous chromosomes takes place in this
- Synapsis may be of following
- Procentric : Starting at the
- Proterminal : Starting at the
- Localised random : Starting at various points.
- Paired chromosomes are called bivalents, which by furthur molecular packing and spiralization becomes shorter and
- Pairing of homologous chromosomes in a zipper-fashion. Number of bivalents (paired homologous chromosomes) is half to total number of chromosomes in a diploid cell. Each bivalent is formed of one paternal and one maternal chromosome (e. one chromosome derived from each parent).
- Under EM, a filamentous ladder like nucleoproteinous complex, called synaptinemal. Complex between the homologous chromosomes which is discovered by “Moses” (1953).
- In the tetrad, two similar chromatids of the same chromosome are called sister chromatids and those of two homologous chromosomes are termed non-sister
- Crossing over e. exchange of segments between non-sister chromatids of homologous chromosome occurs at this stage.
It takes place by breakage and reunion of chromatis segments. Breakage called nicking, is assisted by an enzyme endonuclease and reunion termed annealing is added by an enzyme ligase. Breakage and reunion hypothesis proposed by Darlington (1937).
- Chromatids of pachytene chromosome are attached with
- A tetrad consists of two sets of homologous chromosomes each with two chromatids. Each tetrad has four kinetochore (two sister and two homologous).
- A number of electron dense bodies about 100 nm in diameter are seen at irregular intervals within the centre of the synaptonemal complex, known as recombination
- DNA polymerase is responsible for the repair
- At this stage the paired chromosomes begin to separate (desynapsis).
- Cross is formed at the place of crossing over between non-sister
- Homologous chromosomes move apart they remain attached to one another at specific points called chiasmata.
- At least one chiasma is formed in each
- Chromosomes are attached only at the place of
- Chromatin bridges are formed in place of synaptonemal complex on
- This stage remains as such for long
- Chiasmata moves towards the ends of This is called terminalization.
- Chromatids remain attached at the place of chiasma
- Nuclear membrane and nucleolus
- Chromosome recondense and tetrad moves to the metaphase
- Formation of
Fig : Showing crossing over during meiosis
- Bivalents are irregularly and freely scattered in the nucleocytoplasmic matrix. When the diakinesis of prophase-I is completed than cell enters into the metaphase-I.
network showing chromomeres
Cell wall Cell membrane
Cell membrane Cell wall
Cell membrane Cell membrane
Pair of homologous chromosomes showing synspsis
Cell membrane Nuclcolus
Nuclear membrane disspearing
Pair of sister chromatids
Non- soster chromatids of homologous chromosomes showing crossing over
Disappearing nucleolus and nuclear membrane
Homologous chromosomes showing chlasma
Fig : A-F Meiosis : Prophase I. A. Cell before entering leptotene, B. Leptotene,
- Zygotene, D. Pachytene, E. Diplotene, F. Diakinesis.
Homologous chromosomes separating from one another terminalleation
Metaphase I : It involves;
- Chromosome come on the
- Due to repulsive force the chromosome segment get exchanged at the
- Bivalents arrange themselves in two parallel equatorial or metaphase Each equatorial plate has one genome.
- Centromeres of homologous chromosomes lie equisdistant from equator and are directed towards the poles while arms generally lie horizontally on the
- Each homologous chromosome has two kinetochores and both the kinetochores of a chromosome are joined to the chromosomal or tractile fibre of same
- It involves separartion of homologous chromosomes which start moving opposite poles so each tetrad is divided into two daughter dyads. So anaphase-I involves the reduction of chromosome number, this is called disjunction.
- The shape of separating chromosomes may be rod or J or V-shape depending upon the position of
- Segregation of mendalian factors or independent asortment of chromosomes take place. In which the paternal and maternal chromosomes of each homologous pair segregate during anaphase-I which introduces genetic
- Two daughter nuclei are formed but the chromosome number is half than the chromosome number of mother
- Nuclear membrane
- After telophase I cytokinesis may or may not
- At the end of Meiosis I either two daughter cells will be formed or a cell may have two daughter
- Meiosis I is also termed as reduction
- After meiosis I, the cells in animals are reformed as secondary spermatocytes or secondary oocytes; with haploid number of chromosomes but diploid amount of
(vi) Chromosomes undergo decondensation by hydration and despiralization and change into long and thread like chromation fibres.
Interphase : Generally there is no interphase between meiosis-I and meiosis-II. A brief interphase called interkinesis, or intermeiotic interphase. There is no replication chromosomes, during this interphase.
Cytokinesis-I : It may or may not be present. When present, it occurs by cell-furrow formation in animal cells and cell plate formation in plant cells.
Significance of meiosis-I :
- It separates the homologous chromosomes to reduce the chromosome number to the haploid state, a necessity for sexual
- It introduces variation by forming new gene combinations through crossing over and randon assortment of paternal and maternal
- It may at times cause chromosomal mutation by abnormal
- It induces the cells to produce gametes for sexual reproduction or spores for asexual
Meiosis-II : It is also called equational or homotypical division because the number of chromosomes remains same as after meiosis-I. It is of shorter duration than even typical mitotic division. It is also divisible into two parts, Karyokinesis-II and Cytokinesis-II.
Karyokinesis-II : It involves the separation of two chromatids of each chromosome and their movement to separate cells. It is divided in four phases i.e., Prophase-II, Metaphase-II. Anaphase-II and Telophase-II.
Almost all the changes of Karyokinesis-II resembles to mitosis which involves.
- It starts just after end of telophase
- Each daughter cell (nucleus) undergoes mitotic
- It is exactly similar to
- At the end of process, cytokinesis takes
- Four daughter cells are formed after
- The sister kinetochores of one chromosome are
- The four daughter cells receive one chromatid each of the
- Centromere divide at anaphase II.
- Spindle fibres contract at prophase
Cytokinesis-II : It is always present and occurs by cell furrow formation in animal cell and cell plate formation in plant cell.
So by meiosis, a diploid parental cell divides twice forming four haploid gametes or sex cells, each having half the DNA amount than that of the parental cell and one-fourth of DNA present in the cell at the time of beginning of meiosis.
(5) Significance of meiosis
- Constancy of chromosome number in successive generation is brought by
- Chromosome number becomes half during
- It helps in introducing variations and
- It brings about gamete
- It maintains the amount of genetic informative
- Sexual reproduction includes one meiosis and
- The four daughter cells will have different types of
- Why the necessity of meiosis-II : The basic aim of meiosis is to reduce the number of chromosomes to The chromosomes that separate in the anaphase of meiosis-I are still double. Each consist of two chromatids and has 2n amount of DNA. Thus reduction of DNA content does not occur in meiosis-I. Truely haploid nuclei in
terms of DNA contents as well as chromosome number are formed in meiosis-II. When the chromatids of each chromosome are separated into different nuclei. Thus meiosis-II is necessary.
Difference between Mitosis and Meiosis
|(1)||Site of occurrence||Somatic cells and during the multiplicative phase of gametogenesis in germ cells.||Reproductive germ cells of gonads.|
|(2)||Period of occurrence||Throughout life.||During sexual reproduction.|
|(3)||Nature of cells||Haploid or diploid.||Always diploid.|
|(4)||Number of divisions||Parental cell divides once.||Parent cell divides twice.|
|(5)||Number of daughter cells||Two.||Four.|
|(6)||Nature of daughter cells||Genetically similar to parental cell. Amount of DNA and chromosome number is same as in parental cell.||Genetically different from parental cell. Amount of DNA and chromosome number is half to that of parent cell.|
|(7)||Duration||Shorter (of a few hours) and simple.||Prophase-I is very long (may be in days or months or years) and complex.|
|(8)||Subphases||Formed of 3 subphases : early-prophase, mid-prophase and late-prophase.||Prophase-I is formed of 5 subphases: leptotene, zygotene, pachytene, diplotene and diakinesis.|
|(9)||Bouquet stage||Absent.||Present in leptotene stage.|
|(10)||Synapsis||Absent.||Pairing of homologous
|(11)||Chiasma formation and
|Absent.||Occurs during pachytene stage of prophase-I.|
|(12)||Disappearance of nucleolus and nuclear membrane||Comparatively in earlier part.||Comparatively in later part of prophase-I.|
|(13)||Nature of coiling||Plectonemic.||Paranemic.|
|(14)||Metaphase plates||Only one equatorial plate||Two plates in metaphase-I but one plate in metaphase-II.|
|(15)||Position of centromeres||Lie at the equator. Arms are generally directed towards the poles.||Lie equidistant from equator and towards poles in metaphase-I while lie at the equator in metaphase-II.|
|(16)||Number of chromosomal fibres||Two chromosomal centromere.||fibre||join||at||Single in metaphase-I metaphase-II.||while two||in|
|(17)||Nature of separating chromosomes||Daughter chromosomes (chromatids with independent centromeres) separate.||Homologous chromosomes separete in anaphase-I while chromatids separate in anaphase in anaphase-II.|
|(18)||Splitting of centromeres and development of inter-zonal fibres||Occurs in anaphase.||No splitting of centromeres. Inter-zonal fibres are developed in metaphase-I.|
|(19)||Occurrence||Always occurs||Telophase-I may be absent but telophase-II is always present.|
|(20)||Occurrence||Always occurs||Cytokinesis-I may be absent but cytokinesis-II is always present.|
|(21)||Nature of daughter cells||2N amount of DNA than 4N amount of DNA in parental cell.||1 N amount of DNA than 4 N amount of DNA in parental cell.|
|(22)||Fate of daughter cells||Divide again after interphase.||Do not divide and act as gametes.|
|(23)||Functions||Helps in growth, healing, repair and multiplication of somatic cells.
Occurs in both asexually and sexually reproducing organisms.
|Produces gametes reproduction.||which||help||in||sexual|
|(24)||Variations||Variations are not produced as it keeps quality and quantity of genes same.||Produces variations due to crossing over and chance arrangement of bivalents at metaphase-I.|
|(25)||In evolution||No role in evolution.||It plays an important role in speciation and
- Types of meiosis : On the basis of time and place, meiosis is of three types
- Gametic/Terminal meiosis : In many protozoans, all animals and some lower plants, meiosis takes place before fertilization during the formation of Such a meiosis is described as gametic or terminal.
This type of life cycle with diploid adult and gametic meiosis is known as the diplontic cycle.
- Zygotic or Initial Meiosis : In fungi, certain protozoan groups, and some algae fertilization is immediately followed by meiosis in the zygote, and the resulting adult organisms are Such a meiosis is said to be zygotic or initial. This type of life cycle with haploid adult and zygotic meiosis is termed the haplontic cycle.
(iii) Sporogenetic Meiosis
- Diploid sporocytes or spore mother cells of sporophytic plant, undergo meiosis to form the haploid spores in the
- Haploid spore germinates to form haploid gametophyte which produces the haploid gametes by
- Haploid gametes fuse to form diploid zygote which develops into diploid sporophyte by mitotic
e.g. In higher plants like pteridophytes, gymnosperms and angiosperms.
- Brachymeiosis : Failure of meiosis-II. It is characteristic feature of
- Meiosis-II is not mitosis as it occurs haploid number of chromosomes and chromatids formed may not be similar to each
- Restitution nucleus : A colchicine treated cell has the nucleus with double sets of
- In cyperus, one meiosis produce only one pollen instead of four so that meiotic division required to produce fruits will be = number of fruits ´
- Chiasmata first observed by Janseens (1909).
- When sister chromatids are loosely arranged and are easily It is found in meiotic chromosomes.
- Mitosis ends in 1- 2 hours while meiosis may take 24 hrs to few
- Neuron cells are always in
- When the chromosome duplicates but karyokinesis does not take place the number of chromosome per cell will increases, it is called endomitosis or
- Process of inducing mitosis into a cell –
- To study mitosis root tips are fixed in 1: 3 acetic acid and
- Colchicine inhibits spindle formation and enhance duplication in number of
- At the time of cell division electrostatic force is responsible for
- Mitotic crossing over takes place in parasexual
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